The developments in science and technology are changing our societies at an accelerated pace. While it is undeniable that this type of progress has many positive aspects, it is also causing a break between what the British scientist and philosopher Charles Percy Snow called in his book "The Two Cultures" published in 1959, highlighting the drift between scientific modernity and the "humanities" that are rooted in the long term as well as in questions relating to the meaning of life. This particular falling-out has been accentuated with the secularization of beliefs and consumerist materialism. The skepticism vis-à-vis science as a whole was set in motion with the spread of "fake news" and "alternative theories" via social networks. This has also affected the current environmental crisis which now forces us to consider substantial changes in the way we should design techniques, the way we manufacture, and what type of consumers we are to become in the near future. Bridging this ever-widening gap requires exploring the philosophical implications of science concerning reality and knowledge and linking these insights to the ethical decisions we will have to make in the future, as well as on the technical choices that would ensure a sustainable and desirable future for all. The Mohammed VI Polytechnic University has decided to take on this issue of the utmost importance for the benefit of science students, researchers and engineers as well as for decision-makers and managers. The vision of the "Science and the Quest for Meaning" Center at the Africa Business School is to contribute to the development of a constructive debate between science, technology, culture and philosophy (including metaphysics) at the national, regional and international level, particularly in a Muslim context, and to create the conditions for a more harmonious world for the 21st century.